Circuit mechanisms of acquired epileptogenesis

Abstract

The time course of development of spontaneous recurrent seizures is a sigmoid function of time after status epilepticus or perinatal stroke, which reflects underlying mechanisms of epileptogenesis. The increase in recurrent excitation after axon sprouting, along with death of specific Îd (GABA)ergic interneurons, may contribute to this temporal pattern of epileptogenesis. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.