Comparison between leukocyte esterase activity and histopathological examination in identifying chorioamnionitis

Abstract

Objective To compare the sensitivity and specificity of leukocyte esterase activity (LEA) to histopathological examination in diagnosing chorioamnionitis. Methods We compared the diagnostic tests performed at Dr. Mohammad Hoesin Hospital, Palembang, Indonesia, from September 2015 to April 2016. Ninety-one pregnant women were included in the study. The LEA and histopathological examination were carried out with neonatal sepsis the main outcome. Data were analyzed using the SPSS version 21.0 and MedCalc statistics. Results Chorioamnionitis was detected in 54 (77.1%) patients with a gestational age ≥37 weeks and in 16 (22.9%) patients with a gestational age <37 weeks. The duration of membrane rupture was significantly associated with chorioamnionitis (P = 0.001 and P = 0.011). Neonatal sepsis was also significantly associated with chorioamnionitis in both groups (P = 0.014 and P = 0.036). A LEA value with the cut-off point >0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in the preterm pregnancy group. Conclusion LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy.