Treatment of malignant insulinoma with streptozotocin

Abstract

Two patients with malignant insulinoma and hepatic metastases were treated with streptozotocin, administered directly into the celiac artery. Decreases in tumor size were documented radiographically. One patient was in a terminal state when first treated, but the other patient was in moderately good general health and responded well. Some side-effects, including renal tubular damage, were observed but were relatively minor. Streptozotocin therapy offers some benefit in patients with malignant insulinoma. © 1971 Springer-Verlag.