Verrucous carcinoma. Clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia

Abstract

Verrucous carcinoma, a distinctive variant of epidermoid carcinoma, was found in the oral cavity (77 cases), larynx (12 cases), nasal fossa (4 cases), glans penis (8 cases), vulva (1 case), vagina (1 case), scrotum (1 case). A relationship between the use of chewing tobacco and oral cavity lesions was evident in this indigent, predominantly rural patient group. Locally aggressive behavior with bone invasion occurred in 15 instances. Lymph node metastases were not found except in 4 patients treated by radiation, apparently as a result of alteration of the biologic character of the lesion. Radiation therapy (17 patients) failed to control the lesion in all instances. The response to surgical excision (88 patients) was excellent. Copyright © 1966 American Cancer Society