Biological activities of organometalloid (As, At, B, Ge, Si, Se, Te) Steroids

Abstract

Organometallic steroids (OS) represent an interesting class of biologically active hormones including anabolic steroids. Currently, more than 1,000 OS have been synthesized, and many are widely used in medical practice, including sports medicine and pharmacology. In this review, we present structures of OS that contain (along with the composition of a molecule of metalloids) As, At, B, Ge, Si, Se, and Te. We also used an algorithm that works with a PASS programme containing approximately one million chemical structures and approximately 8,000 validated biological activities and allows you to calculate the predicted activity from the chemical structure of the steroidal molecule. From the huge variety of steroidal structures, we selected more than 100 OS that belong to seven groups, including boronic steroids, arsenosteroids, astatosteroids, germylated steroids, silasteroids, selena steroids and tellura steroids. The biological activity for these groups of OS is presented in this paper. Additionally, it is important to note that these selena and tellura steroids showed a high anticancer activity and they can be used as anti-parkinsonian, anti-Alzheimer's disease and anti-neurodegenerative agents.