Study of estimation of serum LDH and uric acid in preeclampsia and it’s clinical correlation

Abstract

Background: Preeclampsia occurs in 2-8% of pregnancies and a leading cause of maternal and perinatal mortality and morbidity. The objective of this study was to compare serum lactate dehydrogenase (LDH) and uric acid levels in normotensive pregnant women and in women with preeclampsia and to correlate the maternal and perinatal outcomes and severity of the disease with serum LDH and uric acid levelsMethods: A prospective case control study conducted during the period of 18 months involving 100 normotensive pregnant women and an equal no. of patients with preeclampsia admitted under OBG department, Vani Vilas Hospital and Bowring and Lady Curzon hospital, which are affiliated to BMCRI, Bangalore. They were followed up till delivery and early post-partum period. Serum LDH and uric acid levels were sent and maternal and foetal outcomes studied.Results: There was statistically significant increase in levels of serum LDH and uric acid among cases compared to control group. Higher levels were also associated with significant maternal and foetal complications.Conclusions: We conclude from this study that the serum LDH and Uric acid are the inexpensive and reliable markers to predict severity and maternal and foetal outcomes in patients with preeclampsia.