Synthesis and characterization of sodium alginate conjugate: Preparation and evaluation of transdermal patches of losartan potassium using sodium alginate conjugate

Abstract

The aim of the research study was synthesis, and characterization of sodium alginate conjugate and its effect on drug permeation from the transdermal patches consisting of losartan potassium as model drug. The conjugation was achieved by covalent attachment of thiol moieties of L-cysteine to the anionic polymer of sodium alginate, mediated by a carbodiimide. Conjugation was exerted between primary amino groups of polymer and carboxylic acid groups of L-cysteine through amide bond. The synthesized sodium algenate conjugate was characterized by charring point determination, Fourier Transmission Spectroscopic study and differential calorimetric analysis. Matrix type transdermal patches were prepared using different proportions of sodium alginate and sodium alginate conjugate. The patches were evaluated for physicochemical characteristics followed by in vitro and ex vivo permeation studies. The study was concluded that as the proportion of sodium alginate conjugate increased the drug permeation was increased. The mechanism of drug permeation was found to be Non-Fickian profiles.