Treatment of Wuchereria kalimantani infection in Presbytis cristata with a single dose of CGI 18041

Abstract

A new drug for filarial parasite. CGI 18041, was evaluated for the microfilaricidal and macrofilaricidal effects in Presbytis cristata infected with Wuchereria kalimantani. Twenty two microfilaremic leaf monkeys were randomly assigned to the various treatment groups according to their body weight and microfilarial density. They were treated with a single oral dose of 100 mg/kg, 50 mg/kg, 25 mg/kg, 12.5 mg/kg and 6.25 mg/kg CGI 18041. The results showed that CGI 18041 at a single oral dose of 100 mg/kg and 50 mg/kg had complete microfilaricidal and macrofilartcidal effects against W. kalimantani in P. cristata. At a single oral dose of 25 mg/kg CGI 18041 the geometric mean of microfilarial counts (GMMC) were decreased to 0% by day 42 but live adult worms were recovered at autopsy. At a single oral dose of 12.5 mg/kg and 6.25 mg/kg, the drug was found to be effective as a microfilaricidal only; because at autopsy many live adult worms were found.