Inhibition of Helicobacter pylori motility by (+)-syringaresinol from unripe Japanese apricot

Abstract

A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited ≥90% of the H. pylori motility at a concentration of 500 μg/ml and the IC50 value was 50 μg/ml. © 2006 Pharmaceutical Society of Japan.