Core-shell structured hydroxyapatite/mesoporous silica nanoparticle: preparation and application in drug delivery

Abstract

Core-shell nanoparticle is a kind of composite nanomaterials with unique structure and properties, which has important application prospects in the fields of catalysis, biomedicine and photonic crystal, etc. A new kind of materials, core-shell structured HAp@mSiO2 nanoparticles with mesoporous were prepared by improved Stöber coating method using hydroxyapatite (HAp) nanoparticles as core and cetyltrimethylammonium bromide (CTAB) as mesoporous template. By controlling concentration of tetraethyl orthosilicate (TEOS) and its hydrolysis and condensation kinetics, the thickness of mSiO2 shell coating on the core HAp surface could be well regulated. The results of TEM, EDS, XRD, FT-IR, and BET testing show that the prepared HAp@mSiO2 nanoparticles have the characteristics of high specific surface area, narrow pore size and uniform distribution. And using the Ibuprofen as model drug, the prepared materials were tested for drug adsorption and release experiments. It is found that the obtained core-shell structured materials also have good drug control properties and pH response characteristics, and can effectively control the drug release rate and release amount through altering the mSiO2 shell thickness.