Synthesis, Structural Characterization, and Antimicrobial Activity Evaluation of New Binuclear Niobium(V) Tartrate Complexes with Biologically Important Drugs

Abstract

The new binuclear niobium(V) complexes of the type [[NbO(L)C 4 H 4 O 6 ] 2 C 4 H 4 O 6 ] (where L = DMH, IMH, IPH, FPH, TMT) were prepared with biologically important drugs and characterized by using elemental analysis; IR, 1 H-NMR, and UV-Vis spectral studies, and thermogravimetric analysis. The molar conductance measurement of all the complexes in DMF solution corresponds to 1 : 1 electrolytic nature. All complexes were of the pure diamagnetic character and were found to have six-coordinate octahedral geometry. The antimicrobial activity of these complexes has been screened against two Gram-positive and two Gram-negative bacteria. Antifungal activity against two different fungi has been evaluated and compared with controls. All the complexes inhibit the growth of both Gram-positive and Gram-negative bacteria to a competent level.