Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases

30Citations
Citations of this article
113Readers
Mendeley users who have this article in their library.

Abstract

The global prevalence of metabolic disorders, such as obesity, diabetes and fatty liver disease, is dramatically increasing. Both genetic and environmental factors are well-known contributors to the development of these diseases and therefore, the study of epigenetics can provide additional mechanistic insight. Dietary interventions, including caloric restriction, intermittent fasting or time-restricted feeding, have shown promising improvements in patients’ overall metabolic profiles (i.e., reduced body weight, improved glucose homeostasis), and an increasing number of studies have associated these beneficial effects with epigenetic alterations. In this article, we review epigenetic changes involved in both metabolic diseases and dietary interventions in primary metabolic tissues (i.e., adipose, liver, and pancreas) in hopes of elucidating potential biomarkers and therapeutic targets for disease prevention and treatment.

Cite

CITATION STYLE

APA

Asif, S., Morrow, N. M., Mulvihill, E. E., & Kim, K. H. (2020, October 15). Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases. Frontiers in Genetics. Frontiers Media S.A. https://doi.org/10.3389/fgene.2020.590369

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free