Analysis of the cerebral mechanisms underlying rehabilitation of the patients after stroke

Abstract

The authors present the results of the comprehensive analysis of the principal cerebral mechanisms involved in the processes of rehabilitation of the patients after stroke based on the review of the literature concerning this issue. The data obtained in the course of original investigations including 203 patients who had undergone stroke confirm and refine the currently available information pertinent to the problem in question. First and foremost, they demonstrate the influence of the demographic, neurophysiological, and clinical factors as well as neuroimaging and ultrasound studies on the parameters of the evoked potentials in the brain of the stroke-affected patients. In addition, they provide a deeper insight into the role of short-term memory in the realization of the motor response. The probable macro- and microstructural, functional, neurochemical, and pathophysiological mechanisms contributing to the rehabilitation of the patients who had undergone stroke are considered with reference to their relationships. Special emphasis is laid on the methods for regulation of these mechanisms.