Enhanced asynchronous Ca2+ oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion

Abstract

Background: FMR1 CGG expansion repeats in the premutation range have not been linked to astrocyte pathophysiology. Results: Premutation cortical astrocytes display decreased Glu transporter expression/activity and enhanced asynchronous Ca2+ oscillations. Conclusion: Glu transport and Ca 2+ signaling defects in premutation astrocytes could contribute to FXTAS neuropathology. Significance: Premutation astrocytes may have an etiological role in FXTAS neuropathology. Copyright © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.