Bifunctional ligand promoted Pd-catalyzed asymmetric allylic etherification/amination

Abstract

A serious of bissulfoxide-phosphine ligands are examined on the Bronsted basicity of sulfinyl moiety. The effect of secondary binding property of the ligand is demostrated in Pd-catalyzed asymmetric allylic etherification and amination (up to 99% ee). And the application scope of this methodology to hydrogen-donor nucleophiles is investigated. © 2013 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.