Development of trimethoprim drug and innovation of sulfazane-trimethoprim derivatives as anticancer agents

Abstract

Cancer tumors cause not few deaths among the total deaths in the world, despite the great progress in the treatment of cancer, so it has become necessary to understand the molecular explanations that contribute to the development and progress of cancer and to search for more effective and less toxic treatments to treat this disease.The work included the innovation and development of the drug trimethoprim by linking it with the innovative compound sulfazane and creation of several derivatives of sulfazane -trimethoprim for the first time then studying the behavior and impact of innovative compounds on vital activities as anti-cancer tumors by following an innovative procedures of preparation for sulfazane compounds,then linking them with several chemical reactions with the drug trimethoprim to develop its effectiveness and efficiency. Several spectral techniques were used to diagnose and demonstrate the formation of innovative derivatives (sulfazane- trimethoprem) thereof (FT.IR - Spectra,H.NMR - Spectra, HMBC- Spectrum,Mass Spectra), chemical properties, Flowing through TLC,in addition to laboratory study of cancerous tumors. The results indicated to formation of these drug derivatives by appearance of new bands and disappearance of bands in starting compounds., besides to conclusions from our paper that gave good data for inhibition efficiency for these drug derivatives against cancer cells.