Sequence and organization of the human mitochondrial genome

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Abstract

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs. © 1981 Nature Publishing Group.

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Anderson, S., Bankier, A. T., Barrell, B. G., De Bruijn, M. H. L., Coulson, A. R., Drouin, J., … Young, I. G. (1981). Sequence and organization of the human mitochondrial genome. Nature, 290(5806), 457–465. https://doi.org/10.1038/290457a0

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