Approach towards developing a novel procedure to selectively quantify topically applied substances in the hair follicles of the model tissue porcine ear skin

Abstract

Hair follicles represent reservoirs for localized drug therapy and transport pathways for systemic drug delivery. This study describes an approach towards developing a novel procedure for quantifying topically applied substances located in the hair follicles of porcine ear skin, a model for human in vivo skin, using a fluorescent dye. Approximately 5% of the topically applied dye was recovered from the hair follicles, which is in accordance with a previous study. © 2013 John Wiley & Sons A/S.