"On-water" Hiyama coupling catalyzed by CNC pincer complexes of Pd(II)

Abstract

The catalytic activity of two hydrophilic CNC-type palladium pincer complexes is evaluated in the coupling between trimethoxyphenylsilane and aryl bromides. A wide range of assays is performed for each palladium source, and alkaline aqueous conditions turn out to be the most efficient for the target Hiyama coupling, which is applied to the synthesis of several biaryls. In addition, the direct reuse of the aqueous layer containing the catalyst is also conducted with good yield. © ARKAT USA, Inc.