Photoadaptation: A path toward rational phototherapy protocols

Abstract

Photoadaptation is defined as the diminished future response to equivalent doses of irradiation. It is most often estimated in vivo by looking at changes in the minimal erythema dose with subsequent doses of UV radiation. Although photoadaptation's mechanism of action is poorly understood, Palmer et al. help clarify the clinical significance of photoadaptation for the dosimetry of UV-based phototherapy. © 2006 The Society for Investigative Dermatology.