Interaction of isoindole derivatives with compounds acting as0 electron scavengers

Abstract

Fluorescence quenching of isoindole derivatives by compounds acting as electron scavengers was investigated. Water-soluble isoindol-glycine and isoindole-phosphatidylserine in the form of liposomes were obtained by reaction of the corresponding amino compounds with o-phthaldialdehyde. Both isoindoles were found to be highly sensitive to quenching, which occurs with no shift of the emission maximum. Among the quenchers examined, those having heavy atoms and those known as efficient electron scavengers were found to be most effective. Analysis of the quenching kinetics indicates a predominantly collisional mechanism. The quenchers, which can act as proton donors (amides and amino acids), also diminish the stability of the isoindoles. © 1990.