Understanding age-related macular degeneration

Abstract

Second edition. This text covers recent advances in pathophysiology, diagnosis, and treatment of age-related macular degeneration. Section 1. Anatomy, physiology, and pathology of the macula -- 1. Normal anatomy of the macula -- 2. Animal models for age-related macular degeneration -- 3. Pathogenesis and pathophysiology of age-related macular degeneration -- 4. Etiology of late age-related macular disease -- 5. Histopathology of age-related macular degeneration -- section 2. Classification of age-related macular degeneration -- 6. Classification of exudative age-related macular degeneration -- 7. Polypoidal choroidal vasculopathy -- 8. Retinal angiomatous proliferation in age-related macular degeneration -- 9. Differential diagnosis of age-related macular degeneration -- section 3. Imaging -- 10. Fluorescein angiography -- 11. Indocyanine green angiography in age-related macular degeneration -- 12. Fundus autofluorescence imaging in age-related macular degeneration -- 13. Optical coherence tomography -- section 4. Nonexudative age-related macular degeneration -- 14. Antioxidants and age-related macular degeneration : clinical associations and basic mechanisms -- section 5. Exudative age-related macular degeneration -- 15. Pre-anti-VEGF era -- 16. Macugen for age-related macular degeneration -- 17. Lucentis (Ranibizumab) -- 18. Bevacizumab for the treatment of exudative age-related macular degeneration -- 19. VEGF trap-eye for neovascular age-related macular degeneration -- 20. Radiation for the treatment of wet age-related macular degeneration -- 21. Combination therapy for neovascular age-related macular degeneration -- 22. Fovista, a pegylated anti-PDGF aptamer in wet AMD -- 23. Complications of intravitreal injections -- section 6. Frontiers of therapy -- 24. Introduction to gene therapy and related techniques for retinal disorders and age-related macular degeneration -- 25. New pharmacotherapies for age-related macular degeneration -- 26. Artificial vision, retinal implants, and implantable telescope -- 27. Retinal transplantation.