The application of QCT in the prognostic assessment of mCRC undergoing first-line treatment based on bevacizumab

Abstract

Background: Bevacizumab induces muscle atrophy by changing the gene expression level of muscle tissue. Quantitative computed tomography (QCT) enables precise measurement of various body compositions, including muscle area. Materials & Methods: A total of 102 patients with metastatic colorectal cancer (mCRC) undergoing first-line chemotherapy based on bevacizumab were enrolled at thirst Affiliated Hospital of the University of Science and Technology of China. Their body compositions were measured respectively 1 month before and 1 month after the treatment. Results: Treatment-related decline in skeletal muscle index and visceral fat infiltration significantly affect patient prognosis. Conclusion: A predictive model constructed by integrating changes in body composition with patient clinical characteristics effectively predicts the 9-month progression-free survival (PFS) of patients with mCRC.