Adolescent Brain Development Following Early Life Stress: A Systematic Review of White Matter Alterations from Diffusion Tensor Imaging Studies

Abstract

Experiences of early life stress are associated with long-term socioemotional, cognitive and mental health challenges. Despite the growing interest in elucidating the neurobiological consequences of early life stress, relatively little is known about its specific impacts on adolescent white matter maturation. The objective of this systematic review was to consolidate the current literature on neuroimaging studies utilizing diffusion tensor imaging to investigate white matter correlates of early life stress experiences in adolescents (10–25 years). A comprehensive search of online databases identified 546 studies, with 22 studies meeting the inclusion criteria. Early life stress was consistently associated with alterations across several white matter pathways, across Association, Projection and Commissural tracts. Compared to healthy controls, perturbed white matter integrity was observed in adolescents with early life stress exposure, as indexed by both increased and decreased fractional anisotropy. Compromised white matter integrity can have extensive impacts on adolescent development and associated functioning, including emotional dysregulation, mood instability, executive dysfunction, and sensorimotor impairments. Limitations of the current evidence base include the inconsistencies in the measurement of early life stress exposure and the lack of longitudinal research. Future investigations should track developmental trajectories of early life stress exposure and determine how this impacts adolescent neural connectivity.