Another hijack! Some enteroviruses co‐opt the c10orf76/ PI 4 KB complex for their own good

Abstract

Enteroviruses, members of the Picornaviridae family, are non‐enveloped and single‐stranded RNA viruses responsible for several human diseases. During infection, these viruses build membrane‐bound organelles, called replication organelles ( RO s), where new virions are assembled. RO s are highly enriched in phosphatidylinositol 4‐phosphate ( PI 4P) produced by the host lipid kinase PI 4 KB . In this issue of EMBO Reports , McPhail et al [1] characterize a complex, formed by PI 4 KB and the c10orf76 protein, which is involved in PI 4P production. They show that this machinery is hijacked by specific enteroviruses such as coxsackievirus A10 for their replication.