Hamigerone and dihydrohamigerone: Two acetate-derived, antifungal metabolites from Hamigera avellanea

Abstract

The fungus Hamigera avellanea is found to be the source of two metabolites, hamigerone (C25H32O5) and dihydrohamigerone (C25H34O5), the former exhibiting in vitro growth inhibitory activity against phytopathogenic fungi. Their chemical structures and configurations, save for details related to the stereochemistry, have been established by a variety of spectroscopic techniques. Feeding the fungus with specifically labelled 13C-precursors served to establish the biosynthetic derivation of the two metabolites from ten intact acetate and five methioninederived C1-units. © Acta Chemica Scandinavica 1997.