Thermal Cope reaction of 2-azetidinone-tethered 1,5-dienes: Synthesis of tetrahydroazocinones

Abstract

We report herein full details of the first example of a Cope rearrangement in which the C3-C4 bond of the β-lactam nucleus is the central bond of the 1,5-hexadiene system, thus providing an easy and efficient entry to novel, and in some cases optically pure functionalized azocinones.