Non-Smad signaling pathways of the TGF-β family

Citations of this article
Mendeley users who have this article in their library.


Transforming growth factor b (TGF-β) and structurally related factors use several intracellular signaling pathways in addition to Smad signaling to regulate a wide array of cellular functions. These non-Smad signaling pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream cellular responses. This reviewsummarizes the current knowledge of the mechanisms by which non-Smad signaling pathways are directly activated in response to ligand binding, how activation of these pathways impinges on Smads and non-Smad targets, and howfinal cellular responses are affected in response to these noncanonical signaling modes.




Zhang, Y. E. (2017). Non-Smad signaling pathways of the TGF-β family. Cold Spring Harbor Perspectives in Biology, 9(2).

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free