Constituents of Cimicifugae Rhizoma. I. Isolation and Characterization of Ten New Cycloartenol Triterpenes from Cimicifuga heracleifolia Komarov

Abstract

Ten new highly oxidized cycloartane-type triterpenoids, 24-epi-7,8-didehydrocimigenol, 7,8-didehydrocimigenol, 25-0-acetyl-7,8-didehydrocimigenol, 3-keto-24-epi-7,8-didehydrocimigenol, 2‘,4’-O-diacetyl-24-epi-7,8-didehydrocinii-genol-3-xyloside, 3’-O-acetyl-24-epi-7,8-didehydrocimigenol-3-xyloside, 24-epi-7,8-didehydrocimigenol-3-xyloside, 7,8-didehydro-24-O-acetylhydroshengmanol-3-xyloside, 24-epi-acerinol and heracleifolinol, were isolated from the rhizome of Cimicifuga heracleifolia Komarov and their structures were determined by the use of two-dimensional nuclear magnetic resonance (2D NMR) techniques (1H-1H correlation spectroscopy (COSY), 1H-13C COSY, 1H-13C long-range COSY) and by X-ray diffraction analysis of the 3-keto compound. © 1993, The Pharmaceutical Society of Japan. All rights reserved.