Flavonol glycosides from Aristeguietia discolor and their inhibitory activity on electrically-stimulated guinea pig ileum

Abstract

The present study reports the isolation of a new flavonol glycoside, 3,5,6,7,8,4′-hexahydroxyflavone-3-O-α-L-rhanmopyranosyl-(1→6)- β-D-galactopyranoside (1) along with 3,5,6,7,8,4′-hexahydroxyflavone-3-O-α-L-rhamnopyranosyl-(1→6)- β-D-glucopyranoside (2), kaempferol-3-O-rutinoside (3) and rutin (4) from the MeOH extract of Aristeguietia discolor (Asteraceae). In addition, five known cinnamic acid derivatives 5-9 were detected in the same extract. The structure of the new glycoside 1 was elucidated by spectral methods including 1D TOCSY and 2D DQF-COSY. The pharmacological activity of the extracts, and some partially purified fractions and pure compounds were studied on the guinea-pig contractions in vitro. © Swets & Zeitlinger.