Hyperuricemia as a predictor and screening tool for preeclampsia

Abstract

Introduction: preeclampsia is a hypertensive condition that negatively affects the pregnant woman and fetus, producing complications such as morbidity and mortality. Uric acid plays a role in the development of preeclampsia, although there is still no solid evidence to support this theory. This parameter is an additional tool in the screening for preeclampsia, which allows health personnel to identify and treat this complication early. Objective: describe hyperuricemia as a predictor and screening tool for preeclampsia. Methods: a review was carried out in different databases such as PubMed, Scopus and LILACS. After searching and filtering the results obtained, 8 articles were selected and analyzed accordingly. Result: the elevation of serum uric acid concentration preceded by a hypertensive state in pregnant women, especially during the first trimester, especially in complicated pregnancies and with a high risk of developing preeclampsia. In addition, it has been suggested that the measurement of this and other biomarkers that contribute to oxidative stress may help in the control and early treatment of the disease. Conclusion: hyperuricemia can be useful as a predictor and screening tool for preeclampsia, allowing to determine the severity of the pathology and the appearance of complications.