microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.
CITATION STYLE
Greco, S., Zaccagnini, G., Voellenkle, C., & Martelli, F. (2016). MicroRNAs in ischaemic cardiovascular diseases. European Heart Journal, Supplement, 18, E31–E36. https://doi.org/10.1093/eurheartj/suw012
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