MicroRNAs in ischaemic cardiovascular diseases

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Abstract

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.

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Greco, S., Zaccagnini, G., Voellenkle, C., & Martelli, F. (2016). MicroRNAs in ischaemic cardiovascular diseases. European Heart Journal, Supplement, 18, E31–E36. https://doi.org/10.1093/eurheartj/suw012

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