The effect of local endometrial injury and GnRH agonist on pregnancy rate in patients with recurrent implantation failure

Abstract

Objectives: These days, infertility is one of the most common diseases in the community involving 10%-15% of the couples. One method of infertility treatment is assisted reproductive technology (ART). Recently studies have shown that local endometrial injury in patients treated with in vitro fertilization (IVF) cause treatment failure and subsequently decrease the implantation rates. The aim of this study was to show the direct relationship between local endometrial injury and increasing recurrent implantation failure (RIF). Materials and Methods: Our study populations included patients that experienced at least two or more RIFs during IVF which was performed in the Department of Obstetrics and Gynecology of Tabriz University of Medical Sciences. Results: In this study, 76 patients that experienced at least two or more RIFs during IVF were studied. Any local endometrial injury was examined in regard to its affect on the pregnancy rate. The results showed that there is not any relationship between the mean duration of infertility with and without endometrial trauma and IVF in patients. Conclusion: Seven patients with endometrial trauma and 6 patients without endometrial trauma before IVF showed positive βHCG test. Meanwhile there were not significant differences between βHCG test in patients with and without local endometrial injury before IVF. Significant correlation was not found between the incidences of pregnancy after IVF in patients with other parameters.