Differential regulation of cyclin D1 expression by protein kinase Cα and ∈ signaling in intestinal epithelial cells

Abstract

Background: Tight control of cyclin D1 expression is critical for intestinal homeostasis. Results: Whereas PKCα suppresses cyclin D1 expression, PKC∈ up-regulates cyclin D1 via an ERK and NF-κB/CRE- mediated transcriptional mechanism. Conclusion: Cyclin D1 levels in intestinal cells reflect a balance between PKCα and PKC∈ signaling. Significance: The opposing effects of PKCα and PKC∈ on cyclin D1 accumulation reflect their contrasting contributions to intestinal tumorigenesis. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.