Chitosan-Based Nanocarriers for Delivery of Remdesivir

3Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Stable multicomponent capsules for the delivery of remdesivir (Veklury®) are produced through subsequent electrostatic adsorption of oppositely charged components on oil emulsion droplets. For the first time, the encapsulation and release of the medicine Veklury® from polymer capsules was reported. In this study, the effect of the physicochemical properties of chitosan on the size and stability of the produced structures is investigated, on the loaded amount of drug and on the kinetics of drug release in conditions close to the physiological ones. Microbiological studies of the capsules and their constituents were performed via in vitro assays against HCT-8 cell lines and human coronavirus HCoV-OC43. A detailed analysis was performed on the influence of the properties of produced capsules on cytotoxicity against the chosen cell line, as well as their effect on the replication cycle of the virus, the virucidal activity of the samples against the viability of the extracellular virions, and their effect on viral adsorption on the cell membrane.

Cite

CITATION STYLE

APA

Milkova, V., Kamburova, K., Martinov, P., Vilhelmova-Ilieva, N., & Rashev, V. (2023). Chitosan-Based Nanocarriers for Delivery of Remdesivir. Scientia Pharmaceutica, 91(3). https://doi.org/10.3390/scipharm91030037

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free