Abstract
The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.
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Marx, C., Gregianini, T. S., Lehmann, F. K. M., Lunge, V. R., de Carli, S., Dambrós, B. P., … Ikuta, N. (2013). Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil. Memorias Do Instituto Oswaldo Cruz, 108(3), 392–394. https://doi.org/10.1590/S0074-02762013000300021
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