Impact of DNA Oxidation on Toxicology: From Quantification to Genomics

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Abstract

Understanding the toxicological implications of deoxyribonucleic acid (DNA) oxidation arising from cellular oxidative stress depends on identifying DNA oxidation products, their location in the genome, and their interaction with repair, replication, and gene expression.

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Wu, J., Sturla, S. J., Burrows, C. J., & Fleming, A. M. (2019). Impact of DNA Oxidation on Toxicology: From Quantification to Genomics. Chemical Research in Toxicology, 32(3), 345–347. https://doi.org/10.1021/acs.chemrestox.9b00046

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