Synthesis, Molecular Docking And Anticancer Activity Of New Pyridyl-1,2,4-Triazole-Thioglycosides And Their Pyridyl-[1,2,4]Triazolo[1,5-A]Pyridine-Glycoside Analogues

Abstract

Cancer remains a main threat for human life and requires intensive research for discovering and developing treatment strategies. The design and synthesis of novel functionalized and hybrid structures as candidates for anticancer activity investigation have been proven in the literature as an efficient approach for providing a variety of compounds. In the current work, new compounds of hybrid structures incorporating aryl- or heteroarylpyridine, 1,2,4-triazole, glycosyl moieties have been prepared via a stepwise pathway starting from simple available starting compounds. The anticancer activity against MCf-7, PC3 and A549 human cancer cell lines revealed that substituted 1,2,4-triazole-thiol based substituted pyridine structure and the N-glycosyl derivative of the 1,2,4-triazolopyridine compounds exhibited the most potent activities against MCF-7 and A549 cancer cells. Molecular docking into EGFR active site and showed good binding affinities via various modes.