Assessment of anti-inflammatory effect of three different silver diamine fluoride-an in vitro study

Abstract

Aim:To compare and evaluate the anti – inflammatory effect of Kedo-SDF, Kids-e SDF and Fagamin SDF. Materials And Methods:The three different Silver diamine fluoride solutions(Fagamin,Kids-e and Kedo) were prepared in different test tubes. 1 ml of the silver diamine fluoride solution was added to 10-20 ml disilled water at various fixations. This was added to 0.45 mL bovine serum albumin. pH of the mixture was acclimated to 6.3 with 1N hydrochloric acid. Absorbance was measured spectrophotometrically at 660 nm. Diclofenac sodium was used as the standard group. Results: At 40μL concentration KedoSDF had higher anti inflammatory as compared to the other groups including the standard group. At 50μL concentration Kedo SDF and Kids-e SDF had equal anti-inflammatory action and it was higher than Fagamin SDF and the standard group. Conclusion: It can be concluded that Kedo silver diamine fluoride solution exhibited higher anti-inflammatory activity as compared to Fagamin solution and Kids-e solution and hence it can be used. The authors also recommend to conduct in-vitro studies in the future based on the anti-inflammatory action of different specimens of silver diamine fluoride.