ProbSeq - A fragmentation model for interpretation of electrospray tandem mass spectrometry data

Abstract

We describe a probabilistic peptide fragmentation model for use in protein databank searching and de novo sequencing of electrospray tandem mass spectrometry data. A probabilistic framework for tuning of the model using a range of well-characterized samples are introduced. We present preliminary results of our tuning efforts. Copyright © 2004 John Wiley & Sons, Ltd.