Role of apoptotic proteins in REC-2006 mediated radiation protection in hepatoma cell lines

Abstract

The present study was carried out to evaluate the role of apoptotic proteins in REC-2006-mediated radiation protection in hepatoma cell lines. REC-2006 treatment 2h before irradiation strongly inhibited the cleavage of ATM and PARP-1 in HepG2 cells. The expression of nuclear apoptosis inducing factor (AIF) was found to be more inhibited (∼17%) in HepG2 cells in REC-2006 + radiation-treated group. More inhibition (∼33%) of cytochrome c was observed in HepG2 cells upon REC-2006 treatment 2h prior irradiation. Similarly, significantly more (P