Treatment of metastatic uveal melanoma

Abstract

Uveal melanoma is a rare malignancy with a poor prognosis. The risk of metastatic disease (mainly to the liver) exceeds 50% and is often observed many years after the primary treatment. The methods of local surgical treatment of metastatic lesions in the liver provide some chance for long-term survival but are possible in a small percentage of patients. The therapies currently used as a standard for cutaneous melanoma are not as effective in ocular melanoma. The first drug that prolongs the survival of patients is tebentafusp, but its applicability depends on the presence of HLA-A*02: 01 expression.