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Stringent programming of DNA methylation in humans

Twin Research and Human Genetics (2010) 13(5) 405-411
DOI: 10.1375/twin.13.5.405
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Abstract

We describe a PCR-based method called Amplified Methylation Polymorphism (AMP) for scanning genomes for DNA methylation changes. AMP detects tissue-specific DNA methylation signatures often representing junctions between methylated and unmethylated DNA close to intronexon junctions and/or associated with CpG islands. Identical AMP profiles are detected for healthy, young, monozygotic twins.

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Aung, H. T., Harrison, D. K., Findlay, I., Mattick, J. S., Martin, N. G., & Carroll, B. J. (2010). Stringent programming of DNA methylation in humans. Twin Research and Human Genetics, 13(5), 405–411. https://doi.org/10.1375/twin.13.5.405

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