Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and pin1 protein is important for the completion of cytokinesis

Abstract

Background: Evidence is lacking to explain how septin function is controlled during the cell cycle. Results: Phosphorylation of SEPT9 by Cdk1 creates a binding site for Pin1 that is required for cytokinesis. Conclusion: Septin interaction with Pin1 is controlled by Cdk1 and is necessary for timely cytokinesis. Significance: Improper cell division results in cancer, in which both SEPT9 and Pin1 have been implicated. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.