Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)

Abstract

Background: Interleukin-32 participates in responses to viral infection, but how virus induces its expression and the mechanisms of its antiviral activities remain unclear. Results: Interleukin-32 selectively stimulates IFN-λ1 via activating distinct regulatory elements in the promoter. Conclusion: Interleukin-32 promotes IFN-λ1-mediated antiviral response. Significance: Interleukin-32 is one immune response factor and plays an important role in the control of viral infection. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.