Steady-state model calculations predicting the influence of key parameters on the lower detection limit and ruggedness of solvent polymeric membrane ion-selective electrodes

Abstract

Using a previously described steady-state model, the influence of various parameters on the response function of ion-selective electrodes is investigated. The parameters studied include activities of interfering ions of the sample and inner solution, selectivity coefficients lipophilicity of the analyte, concentrations of ionophore and lipophilic ionic sites in the membrane, the thickness of the Nernstian diffusion layer and the membrane as well as the diffusion coefficients in both phases. The results obtained provide indications as to how the lower detection limit of potentiometric sensors and their ruggedness can be improved.