Optimization of Floating Tablet Containing Glibenclamide Using Simplex Lattice Design

Abstract

Glibenclamide is a second generation sulfonyl ureas drug that are widely used in diabetes type 2 therapy. Glibenclamide in floating tablet formulations is used to improve the bioavailability. The aim of this study was to determine the optimum composition of floating tablets of glibenclamide by simplex lattice design. The tablets were prepared by wet granulation technique, using HPMC K100LV and Carbopol 940 as polimers. The optimum formula was determined based on numeric method with physical properties, floating characters, and dissolution profile of tablets. the results of the study show that glibenclamide floating tablets have good physicochemical properties. The combination of HPMC K100LV and Carbopol 940 decreases floating lag time and dissolution rate of floating glibenclamide tablets. The optimum composition of glibenclamide floating tablet was HPMC K100LV 44.29 mg and Carbopol 940 15.71 mg with desirability value 0.989.