POTENTIAL IMPACT OF MARJORAM ON CORAGEN-INDUCED PHYSIOLOGICAL AND HISTOLOGICAL ALTERATIONS IN MALE ALBINO RATS

Abstract

Insect control has been accomplished by insecticides many years ago. Such insecticides can be useful in dealing with insects in our environment; but when they are used wrongly, they have hazards to the environment too. The current study continues to evaluate the potential alleviative effects of marjoram (Origanum majorana L.) on coragen-induced alterations in hematological and hormonal parameters, as well as renal and testicular structure, in male albino rats. Thirty adult male albino rats (Sprague-Dawely) were randomly separated into 3 groups (n=10). The first group received orally 1.0 mL distilled water only; the second group was treated orally with a sublethal dose of coragen suspension (2 g/kg body weight in 1.0 mL distilled water); and the third one was treated orally with coragen suspension (2 g/kg body weight in 1.0 mL distilled water) and marjoram suspension (5 g/kg body weight in 1.0 mL distilled water) together, three times a week for 30 days. The results revealed that marjoram alleviated significantly (P<0.05) coragen-induced microcytic anemia, leukocytosis, thrombocythemia, hyperuricemia, kidney dysfunction, alterations in plasma hormones (sex and thyroid hormones, as well as aldosterone levels), and histological changes in kidneys and testes of male rats. In conclusion, marjoram showed a notable effect against the toxicity of coragen in male rats.