Effects of cinnamon on diabetes

Abstract

Diabetes is a condition of the body in which blood sugar level is higher than the normal average value. It is considered as a major cause of morbidity worldwide. According to the data reported in 2015, 420 million people had diabetes worldwide, type 2 diabetes account for 85% of these cases. This shows 9.2% of the overall world population of adults is suffering from diabetes with their number increasing with every year. It occurs in both men and women equally, increasing the early death risk of the individual. A detailed review and analysis of research published in various publications and online research sites including; Pub Med, Web of Science, Biological, SciVerse Science Direct, CINAHL and The Cochrane Library. 4 Researches were selected on C. Zeylanicum (two in-vitro, two in-vivo). But no human study was available. In-vitro C. Zeylanicum showed potential to inhibit the enzyme pancreatic a-]amylase and a-glucosidase which in turn can reduce post prandial glucose absorption through the intestine, can also increase glucose uptake at cellular level membrane translocation of GLT-4. Increase metabolism of glucose and synthesis of glycogen and insulin release is stimulated as well. With potentially cause activity at insulin receptors. The favorable effects of C. Zeylanicum in animals are diabetes related weight reduction, blood fasting glucose level was also reduced. LDL and HbA1c also show improvements. Cinnamomum zeylanicum shows various useful effects both in vitro and in vivo as a therapeutic agent for diabetes. Further study and research is needed to evaluate any unwanted effects.