Abstract
Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC 50 of 18.97 and 10.95 μg/mL, respectively.
Author supplied keywords
Cite
CITATION STYLE
Lúcio, A. S. S. C., Da Silva Almeida, J. R. G., Barbosa-Filho, J. M., Pita, J. C. L. R., Branco, M. V. S. C., De Fátima Formiga Melo, M., … Tavares, J. F. (2011). Azaphenanthrene alkaloids with antitumoral activity from anaxagorea dolichocarpa sprague and sandwith (annonaceae). Molecules, 16(8), 7125–7131. https://doi.org/10.3390/molecules16087125
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
